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Abstract #4259

Beta-amyloid specific in vivo MR imaging with chalcone conjugated gadolinium complex.

Ah Rum Baek1, Hee-Kyung Kim2,3, Garam Choi1, Soyeon Kim1, Bo Kyung Sung1, Byeong Woo Yang1, Heejin Seo1, Sunghwan Hwang1, Kamrul MD Islam1, Hoesu Jung4, Taekwan Lee4, and Yongmin Chang1,2,3,5

1Medical and bioengineering, Kyungpook national university, Daegu, Korea, Republic of, 2Molecular Medicine & BK21 Plus KNU Biomedical Convergence Program, Kyungpook national university, Daegu, Korea, Republic of, 3Institute of Biomedical Engineering Research, Kyungpook national university, Daegu, Korea, Republic of, 4Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Korea, Republic of, 5Radiology, Kyungpook national university, Daegu, Korea, Republic of

A new gadolinium complex conjugated with chalcone derivative (GdL) shows beta-amyloid specific enhancement in vivo MR imaging. The enhanced region in MR image matched well with fluorescence imaging of beta-amyloid plaque, which was stained by thioflavin S. The difference of signal enhancement between GdL and Gadovist in beta-amyloid oligomer supported that GdL has specificity on beta-amyloid. In addition, GdL shows considerable relaxivities even at high field 9.4 T (r1 = 4.60, r2 = 5.71 mM-1s-1) and comparable kinetic stability compared with commercial MRI agents.

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