Abstract #4259

Beta-amyloid specific in vivo MR imaging with chalcone conjugated gadolinium complex.

Ah Rum Baek¹, Hee-Kyung Kim^2,3, Garam Choi¹, Soyeon Kim¹, Bo Kyung Sung¹, Byeong Woo Yang¹, Heejin Seo¹, Sunghwan Hwang¹, Kamrul MD Islam¹, Hoesu Jung⁴, Taekwan Lee⁴, and Yongmin Chang^1,2,3,5

¹Medical and bioengineering, Kyungpook national university, Daegu, Korea, Republic of, ²Molecular Medicine & BK21 Plus KNU Biomedical Convergence Program, Kyungpook national university, Daegu, Korea, Republic of, ³Institute of Biomedical Engineering Research, Kyungpook national university, Daegu, Korea, Republic of, ⁴Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Korea, Republic of, ⁵Radiology, Kyungpook national university, Daegu, Korea, Republic of

A new gadolinium complex conjugated with chalcone derivative (GdL) shows beta-amyloid specific enhancement in vivo MR imaging. The enhanced region in MR image matched well with fluorescence imaging of beta-amyloid plaque, which was stained by thioflavin S. The difference of signal enhancement between GdL and Gadovist in beta-amyloid oligomer supported that GdL has specificity on beta-amyloid. In addition, GdL shows considerable relaxivities even at high field 9.4 T (r₁ = 4.60, r₂ = 5.71 mM^-1s^-1) and comparable kinetic stability compared with commercial MRI agents.

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