Abstract #4260

Development of a novel theranostic NPs composed of Fe3O4, Trastuzumab and indocyanine green for diagnosis and treatment of HER-2 positive breast cancer

Xiaojun Luo¹, Chunwu Zhou¹, Jing Li¹, and Lizhi Xie²

¹Department of Radiology, National Cancer Center/National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ²GE Healthcare, Beijing, China

Superparamagnetic iron oxides can be used as contrast agents for MR T2-weighted imaging. We created multifunctional nanoparticles based on Fe₃O₄, Trastuzumab and indocyanine green (ICG) to target HER2 positive breast cancer cells in vitro and vivo. Firstly, internalization was assessed on HER-2 positive breast cancer SK-BR-3 cells by transmission electron microscopy (TEM). Furthermore magnetic resonance imaging (MRI) and fluorescence imaging were used to examine the biodistribution and its targeting effect in vivo. Additionally, photothermal therapy (PTT) was further evaluated to examine the treatment effect of NPs. As a result, Fe₃O₄-trastuzumab-ICG have shown great potential to become an effective multifunctional imaging agent and a tool for photothermal therapy for HER-positive breast cancer.

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