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Abstract #4272

In vivo Fast Field Cycling Relaxometry reports on the extra- and intracellular localization of iron oxide particles in tumour mice models.

Simonetta Geninatti Crich1, Maria Rosaria Ruggiero1, Simona Baroni1, Smeralda Rapisarda1, and Silvio Aime1

1University of Torino, Torino, Italy

A new sensitive, non invasive, imaging methods capable of a quantitative detection of Tumour Associated Macrophages (TAM) is herein proposed. The method is based the use Fast Field Cycling (FFC) relaxometers to assess the localization of ferumoxytol in TAM in melanoma tumours. The observed 1/T1 NMRD profiles appear highly dependent on the intra or extra cellular localization of the NPs thus allowing an unambiguous TAM quantification.

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