Fluorine-19 MRI is a cellular imaging approach enabling quantitative
‘hot-spot’ imaging with no background. The
utility of 19F-MRI to detect inflammation and cell therapy in vivo could be expanded by improving
the intrinsic sensitivity of the probe by molecular design. We describe a small
molecular weight fluorinated metal chelate (SALTAME) based on a salicylidene-tris(aminomethyl)ethane
core, with solubility in perfluorocarbon (PFC) oils. SALTAME additive to
nanoemulsion is a potent accelerator of 19F T1 and increases
the image sensitivity per time with signal averaging. We assessed the biocompatibility,
potential 19F signal enhancement and use for detecting inflammation macrophages
in mice in vivo.
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