Abstract #4277

Pyruvate keto-enol tautomerization and its potential impact on apparent pyruvate T1

Justin YC Lau^1,2, Liam AJ Young¹, Jack JJJ Miller^1,2, Christopher T Rodgers^1,3, and Damian J Tyler^1,2

¹Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Headington, United Kingdom, ²Department of Physiology Anatomy & Genetics, University of Oxford, Oxford, United Kingdom, ³Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom

Pyruvic acid is the most commonly studied metabolic agent for dynamic nuclear polarization. In aqueous solution, pyruvic acid can exist in three forms: hydrate (gem-diol), keto, and enol. The composition depends on pH. This study investigates the differences in longitudinal relaxation properties of the three tautomers with the objective of further understanding the factors contributing to the apparent T₁ of pyruvic acid.

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