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Abstract #4278

Investigating Pre-Saturation of Inflowing Lactate for Improving Human Hyperpolarized 13C-Pyruvate Brain Studies

Jeremy W Gordon1, Shuyu Tang1, Hsin-Yu Chen1, Daniel B Vigneron1, and Peder EZ Larson1

1UCSF, San Francisco, CA, United States

Dissolution dynamic nuclear polarization has enabled real-time metabolic imaging in both pre-clinical and clinical research applications. However, pre-clinical studies have provided evidence that inflowing metabolites can bias measurements in a number of organs. In this work, we explored the impact of inflowing lactate spins on quantitative hyperpolarized pyruvate 13C MRI of the human brain in a healthy volunteer. We provide evidence in a healthy volunteer that by pre-saturating inflowing lactate to address this confounding factor, kPL values in the brain were reduced by ~15%. Further studies will increase the sample size to better characterize this effect.

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