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Abstract #4283

Phenylglyoxylic acid as a generic UV-induced radical precursor to hyperpolarize 13C-labelled substrates for in vivo metabolic studies

Irene Marco-Rius1, Tian Cheng2, Adam P Gaunt2, Saket Patel3, Felix Kreis2, Andrea Capozzi4, Alan J Wright2, Kevin M Brindle2, Olivier Ouari3, and Arnaud Comment2,5

1Institute for Bioengineering of Catalonia, Barcelona, Spain, 2University of Cambridge, Cambridge, United Kingdom, 3Aix-Marseille University, CNRS, ICR, Marseille, France, 4Department of Electrical Engineering, Center for Hyperpolarization in Magnetic Resonance, Technical University of Denmark, Lyngby, Denmark, 5GE Healthcare, Cambridge, United Kingdom

Photo-irradiation of phenylglyoxylic acid (PhGA) using visible light produces a non-persistent radical that, in principle, can be used to hyperpolarize any molecule. We show that PhGA can be used as a radical precursor to polarize photo-sensitive metabolic substrates (such as the gluconeogenic probe 13C-dihydroxyacetone) as well as 13C-glucose. We also present our preliminary DNP data obtained in PhGA-doped samples using a novel custom-built cryogen-free 7T/1.4K polarizer.

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