Abstract #4289

Binomial Excitation for Detection of Hyperpolarized [2-13C]Dihydroxyacetone Metabolism

Mukundan Ragavan¹, Alan W Carter¹, Daniel Downes¹, Anthony Giacalone¹, Keith Michel², James Bankson², and Matthew E Merritt¹

¹Biochemistry and Mol. Bio., University of Florida, Gainesville, FL, United States, ²Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States

In this study, we have employed a simple binomial excitation pulse to follow metabolism of hyperpolarized [2-¹³C]dihydroxyacetone in perfused livers. We demonstrate the utility of binomial pulses in suppressing the hyperpolarized (HP) substrate resonance and maximizing metabolite signal intensities.

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