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Abstract #4290

Partial hyperpolarization transfer to protons in [15N2]urea

Felix Kreis1, Alan Wright1, Rachel Katz-Brull2, and Kevin Brindle1,3

1Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, 2Department of Radiology, Hebrew University of Jerusalem, Jerusalem, Israel, 3Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

Direct observation of 15N hyperpolarization is limited by nitrogen’s low gyromagnetic ratio. We overcome this limitation here by transferring 15N hyperpolarization in [15N2]urea to spin coupled protons. The larger gyromagnetic ratio of the protons will increase the sensitivity of detection provided that there is not a significant loss of polarization during the transfer. We show that our polarization transfer pulse sequence, which has been modified for partial polarization transfer, is tolerant of B1 and centre frequency variations and can be used for dynamic spectroscopy and imaging measurements.

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