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Abstract #4291

Making the Transfer: Exploiting Hyperpolarized Bicarbonate-CO2 Exchange for Increased Signal-to-Noise pH Imaging

David E Korenchan1, Jeremy W Gordon1, Sukumar Subramaniam1, Renuka Sriram1, Peder E Z Larson1,2, Dan B Vigneron1,2, Robert R Flavell1, and John Kurhanewicz1,2

1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Bioengineering, University of California, Berkeley and University of California, San Francisco, San Francisco, CA, United States

Hyperpolarized (HP) [13C]bicarbonate MR imaging can map pH in vivo, but images generally suffer from low CO2 signal-to-noise ratio (SNR). However, rapid bicarbonate-CO2 chemical exchange can increase CO2 SNR via exchange-mediated polarization transfer. We exploit this phenomenon for HP [13C]bicarbonate imaging to boost CO2 SNR by 2.2-fold at pH 7.6, where CO2 SNR is lowest in the physiologic range, by acquiring and summing multiple transients. Tip angles and delays are chosen using a priori knowledge of exchange rate to increase SNR while mitigating pH error. This approach can potentially improve imaging SNR in vivo for studying extracellular acidosis in cancer.

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