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Abstract #4297

Frequency calibration methods for the use of 13C spectral-spatial pulses in human brain

Mary A McLean1,2, James T Grist1, Fulvio Zaccagna1, Frank Riemer1, Basetti Madhu2, Christoffer Laustsen3, Rolf F Schulte4, Martin J Graves1, Kevin M Brindle2, and Ferdia A Gallagher1

1Dept of Radiology, University of Cambridge, Cambridge, United Kingdom, 2Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, 3MR Research Centre, University of Aarhus, Aarhus, Denmark, 4GE Healthcare, Munich, Germany

Spectral-spatial pulses demand accurate frequency setting, which is difficult for studies using hyperpolarized 13C substrates, as the calibration has to be performed prior to the injection of the labelled molecule. In this study we retrospectively analysed human 13C brain studies, comparing three methods of scan calibration: study date, external reference phantom, and 1H frequency. The latter method outperformed the other 2 by a large margin: the SD of differences (predicted minus actual frequency of pyruvate) was 11 Hz with 1H frequency, 39 Hz using study date, and 40 Hz when referenced to an external phantom.

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