Abstract #4297

Frequency calibration methods for the use of 13C spectral-spatial pulses in human brain

Mary A McLean^1,2, James T Grist¹, Fulvio Zaccagna¹, Frank Riemer¹, Basetti Madhu², Christoffer Laustsen³, Rolf F Schulte⁴, Martin J Graves¹, Kevin M Brindle², and Ferdia A Gallagher¹

¹Dept of Radiology, University of Cambridge, Cambridge, United Kingdom, ²Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, ³MR Research Centre, University of Aarhus, Aarhus, Denmark, ⁴GE Healthcare, Munich, Germany

Spectral-spatial pulses demand accurate frequency setting, which is difficult for studies using hyperpolarized ¹³C substrates, as the calibration has to be performed prior to the injection of the labelled molecule. In this study we retrospectively analysed human ¹³C brain studies, comparing three methods of scan calibration: study date, external reference phantom, and ¹H frequency. The latter method outperformed the other 2 by a large margin: the SD of differences (predicted minus actual frequency of pyruvate) was 11 Hz with ¹H frequency, 39 Hz using study date, and 40 Hz when referenced to an external phantom.

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