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Abstract #4302

Lactate production but not pool-size is altered in infiltrative mouse model of human GBM: a 1H MRS and hyperpolarized [2H7,13C6]D-glucose study

Mor Mishkovsky1, Olga Gusyatiner2, Bernard Lanz1, Irene Vassallo2, Marie‐France Hamou2, Rolf Gruetter1,3,4,5, and Monika Hegi2

1Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 2Department of Clinical Neuroscience, Lausanne University Hospital, Lausanne, Switzerland, 3Department of Radiology, University of Geneva (UNIGE), Geneva, Switzerland, 4Department of Radiology, University of Lausanne (UNIL), Lausanne, Switzerland, 5Centre d'Imagerie Biomédicale (CIBM), École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland

Glioblastoma (GBM) is the most malignant primary brain tumor in adults. Aberrant glucose metabolism is considered a hallmark of cancer, via the so called ‘Warburg Effect’. MRS gives the access to study tumor metabolism. 1H MRS enables to quantify the steady state pool size and 13C MRS of hyperpolarized (HP) endogenous compounds provides real time metabolic information which is related to enzymatic activity. The aim of the present study was to examine whether changes in lactate production through glycolysis can be characterized using HP [2H7,13C6]D-glucose MRS, and if those correspond to changes in lactate pool size.

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