Abstract #4302

Lactate production but not pool-size is altered in infiltrative mouse model of human GBM: a 1H MRS and hyperpolarized [2H7,13C6]D-glucose study

Mor Mishkovsky¹, Olga Gusyatiner², Bernard Lanz¹, Irene Vassallo², Marie‐France Hamou², Rolf Gruetter^1,3,4,5, and Monika Hegi²

¹Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ²Department of Clinical Neuroscience, Lausanne University Hospital, Lausanne, Switzerland, ³Department of Radiology, University of Geneva (UNIGE), Geneva, Switzerland, ⁴Department of Radiology, University of Lausanne (UNIL), Lausanne, Switzerland, ⁵Centre d'Imagerie Biomédicale (CIBM), École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland

Glioblastoma (GBM) is the most malignant primary brain tumor in adults. Aberrant glucose metabolism is considered a hallmark of cancer, via the so called ‘Warburg Effect’. MRS gives the access to study tumor metabolism. ¹H MRS enables to quantify the steady state pool size and ¹³C MRS of hyperpolarized (HP) endogenous compounds provides real time metabolic information which is related to enzymatic activity. The aim of the present study was to examine whether changes in lactate production through glycolysis can be characterized using HP [²H₇,¹³C₆]D-glucose MRS, and if those correspond to changes in lactate pool size.

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