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Abstract #4301

Detection of pyruvate carboxylation and age related changes in glycolysis in human brain using hyperpoplarized 13C MR spectroscopy

Albert P Chen1, Casey Y Lee2,3, Benjamin J Geraghty2,3, William J Perks4, Hany Soliman5, and Charles H Cunningham 2,3

1GE Healthcare, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 3Medical Biophysics, University of Toronto, Toronto, ON, Canada, 4Pharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 5Sunnybrook Health Sciences Centre, Toronto, ON, Canada

The feasibility of acquiring hyperpolarized 13C images from human brains following injections of HP [1-13C]pyruvate solution has been recently demonstrated. In this study, following each dynamic 3D volume 13C imaging acquisition (5 s temporal resolution), 13C spectroscopic data were acquired from a large slab through the brain. 13C pyruvate, lactate, alanine and bicarbonate were observed in all volunteer subjects. 13C aspartate was also detect in some of the subjects. Good inter-subject consistency in metabolite ratios as well as potential age related trend were observed in these data.

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