Abstract #4301

Detection of pyruvate carboxylation and age related changes in glycolysis in human brain using hyperpoplarized 13C MR spectroscopy

Albert P Chen¹, Casey Y Lee^2,3, Benjamin J Geraghty^2,3, William J Perks⁴, Hany Soliman⁵, and Charles H Cunningham ^2,3

¹GE Healthcare, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁴Pharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁵Sunnybrook Health Sciences Centre, Toronto, ON, Canada

The feasibility of acquiring hyperpolarized 13C images from human brains following injections of HP [1-13C]pyruvate solution has been recently demonstrated. In this study, following each dynamic 3D volume 13C imaging acquisition (5 s temporal resolution), 13C spectroscopic data were acquired from a large slab through the brain. 13C pyruvate, lactate, alanine and bicarbonate were observed in all volunteer subjects. 13C aspartate was also detect in some of the subjects. Good inter-subject consistency in metabolite ratios as well as potential age related trend were observed in these data.

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