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Abstract #4300

Spiral-IDEAL for Time-Resolved Imaging of Hyperpolarized 129Xe Kinetics in the Rat Brain

Yonni Friedlander1,2, Brandon Zanette1, Marcus Couch1,2, Andrea Kassner1,3, and Giles Santyr1,2

1Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada, 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Department of Medical Imaging, University of Toronto, Toronto, ON, Canada

Rapid, spectrally resolved imaging of 129Xe in the rat brain may allow for measurement of cerebral blood flow, as well as tissue characteristics such as relaxation rates and partition coefficient which may be useful for characterizing neurological disease or injury such as stroke. In this work, the feasibility of spiral-IDEAL for spectrally resolved 129Xe in the rat brain was demonstrated during steady state ventilation of a rat. With future improvements to the signal-to-noise ratio, it is proposed that spiral-IDEAL will allow for rapid, spectrally resolved imaging of the brain.

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