Abstract #4300

Spiral-IDEAL for Time-Resolved Imaging of Hyperpolarized 129Xe Kinetics in the Rat Brain

Yonni Friedlander^1,2, Brandon Zanette¹, Marcus Couch^1,2, Andrea Kassner^1,3, and Giles Santyr^1,2

¹Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada, ²Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Department of Medical Imaging, University of Toronto, Toronto, ON, Canada

Rapid, spectrally resolved imaging of ¹²⁹Xe in the rat brain may allow for measurement of cerebral blood flow, as well as tissue characteristics such as relaxation rates and partition coefficient which may be useful for characterizing neurological disease or injury such as stroke. In this work, the feasibility of spiral-IDEAL for spectrally resolved ¹²⁹Xe in the rat brain was demonstrated during steady state ventilation of a rat. With future improvements to the signal-to-noise ratio, it is proposed that spiral-IDEAL will allow for rapid, spectrally resolved imaging of the brain.

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