Abstract #4299

A Quadrature Detection Technique to Resolve J-Modulated [2-13C]Lactate in Hyperpolarized [2-13C] Pyruvate Imaging

Keshav Datta^1,2 and Daniel Mark Spielman^1,2

¹Radiology, Stanford University, Stanford, CA, United States, ²Electrical Engineering, Stanford University, Stanford, CA, United States

For the imaging of hyperpolarized [2-¹³C]pyruvate, we propose a hybrid approach in which the closely spaced metabolic peaks of pyruvate, glutamate, citrate, acetoacetate, and acetyl-carnitine are measured using spectroscopic imaging, while the highly shifted [2-¹³C]Lactate peak is measured using selective excitation with a conventional fast imaging readout. We further demonstrate that a quadrature image reconstruction algorithm combining data from two fast imaging acquisitions, with the readout shifted by 1/2J, eliminates severe artifacts that normally arise when imaging a J-coupled system for which 1/J is comparable to the readout window.

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