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Abstract #4304

Differentiating Radiation Necrosis from Brain Tumor Using Hyperpolarized Carbon-13 Metabolic MRI

Seulkee Kim1, Biruk Tesfaye Birhanu2, Daniela Pucciarelli3, Chung-Man Moon4, Jin Myung Choi5, Shin Jung5, Woong Yoon2, Jean Nakamura3, and Ilwoo Park2

1Radiology, Chonnam National University Hwasun Hospital, Hwasun, Korea, Republic of, 2Radiology, Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of, 3Radiation Oncology, University of California San Francisco, San Francisco, CA, United States, 4Quantitative Medical Imaging Section, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, United States, 5Neurosurgery, Chonnam National University Hwasun Hospital, Hwasun, Korea, Republic of

The differentiation of recurrent tumor from radiation necrosis after radiation therapy remains often challenging in patients with brain tumor despite various advanced MR imaging techniques. The purpose of this study was to explore the feasibility of hyperpolarized 13C metabolic imaging in differentiating brain tumor from radiation necrosis. The lactate signal in radiation necrosis model was significantly lower than that in glioma and lung cancer metastasis. This suggests that the non-invasive characterization of real-time metabolism using this new neuroimaging method may be helpful for differentiating radiation-induced necrosis from recurrent brain tumors.

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