Abstract #4304

Differentiating Radiation Necrosis from Brain Tumor Using Hyperpolarized Carbon-13 Metabolic MRI

Seulkee Kim¹, Biruk Tesfaye Birhanu², Daniela Pucciarelli³, Chung-Man Moon⁴, Jin Myung Choi⁵, Shin Jung⁵, Woong Yoon², Jean Nakamura³, and Ilwoo Park²

¹Radiology, Chonnam National University Hwasun Hospital, Hwasun, Korea, Republic of, ²Radiology, Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of, ³Radiation Oncology, University of California San Francisco, San Francisco, CA, United States, ⁴Quantitative Medical Imaging Section, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, United States, ⁵Neurosurgery, Chonnam National University Hwasun Hospital, Hwasun, Korea, Republic of

The differentiation of recurrent tumor from radiation necrosis after radiation therapy remains often challenging in patients with brain tumor despite various advanced MR imaging techniques. The purpose of this study was to explore the feasibility of hyperpolarized ¹³C metabolic imaging in differentiating brain tumor from radiation necrosis. The lactate signal in radiation necrosis model was significantly lower than that in glioma and lung cancer metastasis. This suggests that the non-invasive characterization of real-time metabolism using this new neuroimaging method may be helpful for differentiating radiation-induced necrosis from recurrent brain tumors.

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