Abstract #4305

Distinguishing metabolic signals of liver tumors from surrounding liver cells using hyperpolarized 13C MRI and Gadoxetate

Shubhangi Agarwal^1,2, Jeremy Gordon¹, Natalie Korn¹, Robert A Bok¹, Cornelius von Morze^1,2, Daniel B Vigneron^1,2, John Kurhanewicz¹, and Michael A Ohliger^1,2

¹1Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States, ²Liver Center, University of California, San Francisco, CA, United States

Hyperpolarized (HP) ¹³C MRI is a new technique that can assess the metabolic pathways in a variety of tumors. In this study, we show the ability of a gadolinium-based contrast agent (gadoxetate) to selectively suppress the HP metabolic signal arising from normal hepatocytes by altering the relaxation rates of metabolites ¹³C pyruvate and ¹³C lactate in order to evaluate the metabolic profile of tumors within the liver.

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