Abstract #4306

Rapid Visualization of the Effects of Lactate Dehydrogenase Inhibition in Breast Cancer using Hyperpolarized Pyruvate

Cody Callahan¹, Manushka Vaidya¹, Olmo Sonzogni², Jocelin Pinto², Pankaj Seth³, Gerburg Wulf², and Aaron Grant¹

¹Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States, ²Hematology/Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States, ³Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States

High rates of glycolysis in cancer can be targeted by inhibition of lactate dehydrogenase (LDH), the enzyme responsible for conversion of pyruvate into lactate. Hyperpolarized pyruvate was employed to assess the effects of GNE140, a recently developed inhibitor of LDH. Administration of GNE140 results in a sizable reduction in lactate signal within 30 minutes of administration.

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