13C chemical shift images were obtained from orthotopic rat models of glioblastoma prior to and following treatment with Bevacizumab. The resulting change in the hyperpolarized [1-13C]lactate/[1-13C]pyruvate ratio differed depending upon the model used. In U87 tumors the ratio increased and in patient-derived xenografts it decreased, with long term treatment of this latter model producing an invasive phenotype.
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