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Abstract #4310

Hyperpolarised [1-13C]pyruvate imaging of response to Bevacizumab

Richard Mair1,2, Alan Wright2, and Kevin Brindle2

1Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, 2CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom

13C chemical shift images were obtained from orthotopic rat models of glioblastoma prior to and following treatment with Bevacizumab. The resulting change in the hyperpolarized [1-13C]lactate/[1-13C]pyruvate ratio differed depending upon the model used. In U87 tumors the ratio increased and in patient-derived xenografts it decreased, with long term treatment of this latter model producing an invasive phenotype.

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