Meeting Banner
Abstract #4309

Detecting early response to PD-L1 blockade by 13C MRI

Yu Saida1, Tomohiro Seki1, Kazu Yamamoto1, Jeffery R. Brender1, James B. Mitchell1, Murali C. Krishna1, and Shun Kishimoto1

1Radiation Biology Branch, National Cancer Institute, Bethesda, MD, United States

This goal of this study is to detect metabolic changes using hyperpolarized 13C-MRI with [1-13C] pyruvate to evaluate the response to PD-L1 blockade treatment. Lactate/Pyruvate ratio tended to decrease in αPD-L1 antibody treated tumor in mouse model although not statistically significant. We will investigate capability of metabolic imaging to early response to immune checkpoint inhibitor.

This abstract and the presentation materials are available to members only; a login is required.

Join Here