Abstract #4309

Detecting early response to PD-L1 blockade by 13C MRI

Yu Saida¹, Tomohiro Seki¹, Kazu Yamamoto¹, Jeffery R. Brender¹, James B. Mitchell¹, Murali C. Krishna¹, and Shun Kishimoto¹

¹Radiation Biology Branch, National Cancer Institute, Bethesda, MD, United States

This goal of this study is to detect metabolic changes using hyperpolarized 13C-MRI with [1-13C] pyruvate to evaluate the response to PD-L1 blockade treatment. Lactate/Pyruvate ratio tended to decrease in αPD-L1 antibody treated tumor in mouse model although not statistically significant. We will investigate capability of metabolic imaging to early response to immune checkpoint inhibitor.

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