Abstract #4318

Hyperpolarized Dihydroxyacetone Metabolism in the Mouse Liver Under Physiological Perfusion Conditions

Mukundan Ragavan¹, Alan W Carter¹, Daniel Downes¹, Anthony Giacalone¹, Keith Michel², James Bankson², and Matthew Merritt¹

¹Biochemistry and Mol. Bio., University of Florida, Gainesville, FL, United States, ²Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States

Hyperpolarized [2-¹³C]dihydroxyacetone is a promising new molecular imaging agent that is sensitive to hepatic gluconeogenesis as well as glycolytic flux. Here, a physiological perfusion condition produces a metabolic profile in keeping with current understanding of hepatic metabolism, as compared to previous results from a model intended to strongly upregulate gluconeogenesis.

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