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Abstract #4318

Hyperpolarized Dihydroxyacetone Metabolism in the Mouse Liver Under Physiological Perfusion Conditions

Mukundan Ragavan1, Alan W Carter1, Daniel Downes1, Anthony Giacalone1, Keith Michel2, James Bankson2, and Matthew Merritt1

1Biochemistry and Mol. Bio., University of Florida, Gainesville, FL, United States, 2Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States

Hyperpolarized [2-13C]dihydroxyacetone is a promising new molecular imaging agent that is sensitive to hepatic gluconeogenesis as well as glycolytic flux. Here, a physiological perfusion condition produces a metabolic profile in keeping with current understanding of hepatic metabolism, as compared to previous results from a model intended to strongly upregulate gluconeogenesis.

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