Abstract #4322

Non-invasive detection of toxin-induced inflammation in the mouse brain using hyperpolarized 13C MRSI

Lydia Le Page^1,2, Caroline Guglielmetti^1,2, Brice Tiret¹, and Myriam Chaumeil^1,2

¹Physical Therapy and Rehabilitation Science, University of California, San Francisco, San Francisco, CA, United States, ²Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

In recent years, hyperpolarized (HP) ¹³C magnetic resonance spectroscopic imaging (MRSI) has shown promise in assessing neuroinflammation in the brains of mouse models of multiple sclerosis and traumatic brain injury. In this follow-up study, we used ¹³C MRSI of HP [1-¹³C] pyruvate/¹³C urea to assess neuroinflammation following intracranial injection of a toxin, namely lipopolysaccharide (LPS). A significantly elevated lactate:pyruvate ratio was observed in LPS-injected mice, and was associated with a significant increase in the presence of macrophages/microglia and astrocytes as assessed histologically. Our results demonstrate that HP ¹³C MRS has the sensitivity to assess toxin-induced changes in the brain.

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