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Abstract #4321

Ex-vivo investigation of renal metabolic heterogeneity using hyperpolarized [1-13C]pyruvate MRI: a novel renal perfusion device

Christian Østergaard Mariager1, Esben Søvsø Szocska Hansen1, Sabrina Kahina Bech1, Anders Munk2, Mads Dam Lyhne2, Karsten Søberg3, Peter Fast Nielsen3, Steffen Ringgaard1, and Christoffer Laustsen1

1Department of Clinical Medicine, the MR Research Centre, Aarhus University, Aarhus N, Denmark, 2Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark, 3Department of Anesthesia and Intensive Care, Aarhus University Hospital, Aarhus N, Denmark

The mammalian kidney is a complex organ, maintaining the water and nutrient balance of the body. Current knowledge of the essential functions, and the interplay with metabolic processes, are mainly derived from small animal experiments (uni-papilary kidneys) using invasive methods and lacking spatial resolution. The approach presented here addresses these limitations, by introducing a new MR compatible kidney perfusion device, enabling imaging of the underlying metabolic and functional patterns associated with the multi-papillary porcine kidney, better resembeling the human physiology.

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