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Abstract #4320

Flow attenuation and saturation-recovery to discriminate between intracellular and inflowing species in renal hyperpolarized 13C MRS

Alice Radaelli1, Rolf Gruetter1,2,3, and Hikari Ananda Infinity Yoshihara1

1Laboratory for Functional and Metabolic Imaging (LIFMET), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 2Department of Radiology, University of Geneva (UNIGE), Geneva, Switzerland, 3Department of Radiology, University of Lausanne (UNIL), Lausanne, Switzerland

Selective attenuation of signal from flowing hyperpolarized 13C spins can be used to enhance the fraction of signal from locally-produced metabolites. Here, we look at the effect of flow attenuation in the rat kidney on pyruvate metabolite ratios using an interleaved pulse-acquire/spin-echo+bipolar gradient acquisition scheme. With flow-sensitizing gradients applied, lactate- and alanine-to-pyruvate ratios increase as anticipated. Unexpectedly, the ratio of the hydrate and keto forms of pyruvate increases as well, suggesting a greater fraction of flowing keto-pyruvate. The increasing lactate signal fraction after saturation indicates that labelled circulating lactate becomes predominant over the course of the acquisition.

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