Abstract #4320

Flow attenuation and saturation-recovery to discriminate between intracellular and inflowing species in renal hyperpolarized 13C MRS

Alice Radaelli¹, Rolf Gruetter^1,2,3, and Hikari Ananda Infinity Yoshihara¹

¹Laboratory for Functional and Metabolic Imaging (LIFMET), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ²Department of Radiology, University of Geneva (UNIGE), Geneva, Switzerland, ³Department of Radiology, University of Lausanne (UNIL), Lausanne, Switzerland

Selective attenuation of signal from flowing hyperpolarized ¹³C spins can be used to enhance the fraction of signal from locally-produced metabolites. Here, we look at the effect of flow attenuation in the rat kidney on pyruvate metabolite ratios using an interleaved pulse-acquire/spin-echo+bipolar gradient acquisition scheme. With flow-sensitizing gradients applied, lactate- and alanine-to-pyruvate ratios increase as anticipated. Unexpectedly, the ratio of the hydrate and keto forms of pyruvate increases as well, suggesting a greater fraction of flowing keto-pyruvate. The increasing lactate signal fraction after saturation indicates that labelled circulating lactate becomes predominant over the course of the acquisition.

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