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Abstract #4333

Flexible Numerical Simulation Framework for Dynamic PET-MRI

Johannes Mayer1, Kris Thielemans2, Richard Brown2, Evgueni Ovtchinnikov3, David Atkinson4, Paul Marsden5, Tobias Schäffter1,5, and Christoph Kolbitsch1,5

1Physikalisch-Technische Bndesanstalt (PTB), Braunschweig and Berlin, Germany, 2Institute of Nuclear Medicine, University College London, London, United Kingdom, 3Scientific Computing Department, Science and Technology Facilities Council, RAL, Didcot, United Kingdom, 4Centre for Medical Imaging, University College London, London, United Kingdom, 5School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

A numerical simulation framework for dynamic simultaneous PET- MR is presented, which allows for simulated data acquisition of different anatomy with cardiac and respiratory motion and dynamic contrast changes (due to MR contrast agent or PET tracer changes over time). The output of the simulation framework is provided in ISMRMRD and PET interfile raw data format and can be directly used in a range of available reconstruction packages. The reconstructed PET and MR images of the simulated data were compared to an in-vivo patient scan demonstrating that the simulation framework yields realistic data.

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