Abstract #4333

Flexible Numerical Simulation Framework for Dynamic PET-MRI

Johannes Mayer¹, Kris Thielemans², Richard Brown², Evgueni Ovtchinnikov³, David Atkinson⁴, Paul Marsden⁵, Tobias Schäffter^1,5, and Christoph Kolbitsch^1,5

¹Physikalisch-Technische Bndesanstalt (PTB), Braunschweig and Berlin, Germany, ²Institute of Nuclear Medicine, University College London, London, United Kingdom, ³Scientific Computing Department, Science and Technology Facilities Council, RAL, Didcot, United Kingdom, ⁴Centre for Medical Imaging, University College London, London, United Kingdom, ⁵School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

A numerical simulation framework for dynamic simultaneous PET- MR is presented, which allows for simulated data acquisition of different anatomy with cardiac and respiratory motion and dynamic contrast changes (due to MR contrast agent or PET tracer changes over time). The output of the simulation framework is provided in ISMRMRD and PET interfile raw data format and can be directly used in a range of available reconstruction packages. The reconstructed PET and MR images of the simulated data were compared to an in-vivo patient scan demonstrating that the simulation framework yields realistic data.

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