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Abstract #4334

The Value of PET/MR Multimodality Imaging in Assessing Intratumoral Biological Heterogeneity in Patients with Lung Cancer

Peng Yu1, Jing Ning1, Jing Li2, Xiao Zhang2, Yueyong Xiao2, Mu Lin3, Xiang Feng3, Jiajin Liu1, Baixuan Xu1, and Jiahe Tian1

1Department of Nuclear Medicine, Chinese PLA General Hospital, Beijing, China, 2Department of Radiology, Chinese PLA General Hospital, Beijing, China, 3MR Collaboration, Diagnostic Imaging, Siemens Healthcare Ltd, Shanghai, China

Lung cancer is characterized by high intra-tumoral heterogeneity, which potentially increases the difficulties of obtaining accurate biopsy results. By combining CT guided-biopsy of lung masses with previously acquired PET/MR images, we investigated the pathological statuses and gene mutation of tissues samples from different locations within one tumor. The results demonstrated that PET/MR can increase the accuracy of a biopsy as well as enhance our understanding of the complicated biological behaviors of cancers.

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