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Abstract #4348

Measuring J-coupling Mediated CEST for Desmosine, a critical amino acid for lung physiology and pathology

Jesse D Roberts1, Christian Farrar 1, Iris Yuwen Zhou1, and Leo L Cheng2

1MGH/Harvard Medical School, Charlestown, MA, United States, 2Radiology and Pathlogy, MGH/Harvard Medical School, Charlestown, MA, United States

Chemical Exchange Saturation Transfer (CEST) imaging provides the opportunity for probing important metabolic pathways in vivo. However, clinical implementation of the CEST method for metabolic imaging requires overcoming several technical obstacles. To advance the clinical application of this technology, we propose to generate the CEST effects of labile protons that are polarized via J-couplings by neighboring aliphatic protons while the latter undergo radio frequency irradiation. We tested and proved this concept using desmosine, a unique, pyridinium-containing amino acid that is critical for lung physiology and pathology. Additional work will be concentrated on further systematic investigations and in vivo implementations.

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