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Abstract #4347

­­To evaluate the role of APT-w contrast, optimized for normalization and ROIs selection, in differentiating Infective and Neo-plastic Mass Lesions

Ayan Debnath1,2, Rakesh Kumar Gupta3, Dinil Sasi1, Snekha Thakran1, and Anup Singh1,4

1Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, 2Center for Magnetic Resonance & Optical Imaging, University of Pennsylvania, Philadelphia, PA, United States, 3Department of Radiology, Fortis Memorial Research Institute, Gurgaon, Haryana, India, 4Department of Biomedical Engineering, All India Institute of Medical Science, New Delhi, India

Differentiation of intra-cranial-mass-lesions (ICMLs), particularly infective vs neoplastic is difficult using conventional MRI. In the current study, the potential of amide proton transfer weighted (APT-w) contrast for differentiating infective and neo-plastic-mass-lesions has been investigated. APT-w contrast was computed and optimized with respect to different types of normalizations and region-of-interests (ROIs) selection. There was substantial overlap of APT-w contrast values among ICMLs. Different normalizations showed significant difference (P<0.05) in differentiating various groups among ICMLs. Histogram analysis played an important role in significant differentiation (P<0.05) of ICMLs. Thus, APT-MRI can enhance diagnostic accuracy.

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