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Abstract #4346

Diagnostic Performance of Amide Proton Transfer-Weighted MRI for Predicting Histological Grade of Hepatocellular Carcinoma

Yue Lin1, Chunmei Li1, Jinyuan Zhou2, and Min Chen1

1Beijing Hospital, Beijing, China, 2Johns Hopkins University, Baltimore, MD, United States

Amide proton transfer-weighted (APTw) MR imaging has attracted increasing attention in the field of molecular imaging as a novel contrast mechanism in MRI. The purpose of the study was to prospectively evaluate the potential role of APTw-MRI and morphologic features in predicting the histological grade of hepatocellular carcinoma (HCC). We enrolled 32 HCC patients who underwent routine liver sequences and APTw sequence on a 3.0-T MRI scanner. Our results showed higher APTw values and larger tumor size are potential predictive biomarkers for high-grade HCC.

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