Amide proton transfer-weighted (APTw) MR imaging has attracted increasing attention in the field of molecular imaging as a novel contrast mechanism in MRI. The purpose of the study was to prospectively evaluate the potential role of APTw-MRI and morphologic features in predicting the histological grade of hepatocellular carcinoma (HCC). We enrolled 32 HCC patients who underwent routine liver sequences and APTw sequence on a 3.0-T MRI scanner. Our results showed higher APTw values and larger tumor size are potential predictive biomarkers for high-grade HCC.
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