Abstract #4350

In vivo monitoring of Mesenchymal Stem Cells in a rat knee with Tissue Saturation SWIFT

Sergey Magnitsky¹, Michael Garwood², Nancy Lane³, and Djaudat Idiyatullin²

¹CHOP, Philadelphia, PA, United States, ²Radiology, University of Minnesota, Minneapolis, MN, United States, ³UC Davis, Sacramento, CA, United States

Mesenchymal Stem Cells (MSCs) have potentials to be used for the treatment of bone diseases. We developed a new MRI method for detection of Fe-labeled MSCs. This protocol utilizes a resonance frequency shift induced by iron-oxide particles and allows imaging of grafted MSCs with a saturated signal from the host tissue. We compared retention of control and MSCs tagged with a high affinity to the bone tissue peptide. As compared with control, more tagged MSCs were detected at the injection area nine days after implantation. The new protocol allows monitoring grafted cells invivo and opens new opportunities for preclinical studies.

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