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Abstract #4351

MR Visualization of Macrophages’ Damage in Response to X-Irradiation by Detecting Intracellular SPIO Deposition

Masayuki Yamaguchi1, Kazunobu Ohnuki1, Kenji Hotta2, and Hirofumi Fujii1

1Division of Functional Imaging, National Cancer Center, Kashiwa, Japan, 2Division of Radiation Oncology and Particle Therapy, National Cancer Center, Kashiwa, Japan

The MR visualization of radiation treatment margins may be helpful during radiotherapy for liver cancer to monitor early response of the tumor and acute damage in non-tumor liver parenchyma. To demonstrate that MR signals from SPIO-labelled Kupffer cells may be changed in direct relation to the cellular response to x-irradiation, we examined the changes in transverse relaxation rates, R2’ (R2’=R2*-R2) of cell phantoms containing SPIO-labelled and x-irradiated macrophage-like J774A.1 cells in vitro. We found that x-irradiation to macrophages can cause SPIO deposition and R2’ elevation in a dose range of 0 to 10 Gy.

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