Abstract #4355

Potential strategies to test the sensitivity of iron oxide nanoparticles as a spin-lattice MR relaxation contrast agent in vivo.

Joong Hee Kim^1,2 and David Brody^1,2,3

¹Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation, Bethesda, MD, United States, ²Laboratory of Functional and Molecular Imaging, National Institute of Health, Bethesda, MD, United States, ³Neurology, Uniformed Services University of the Health Science, Bethesda, MD, United States

A well designed MR T1 relaxation contrast agent would provide readily detectible MR image contrast without extensive post-processing and superior spatial resolution compared to other MRI derived biomarkers. However, developing effective an T1 contrast agent would require comprehensive in vivo preclinical study. Thus, it would be highly beneficial to have methodology which can provide quantitative assessment on the relaxation effects of the employed contrast agent on living tissue without damaging the tissue integrity. Here we present a potential strategy to test MR sensitivity on T1 contrast agent on living tissue. The digital simulation provided quantitative assessment on T1 relaxation effect.

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