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Abstract #4357

Investigation of halo-artifacts using improved scatter correction in 68-Ga-PSMA PET/MRI of the prostate

Maike E Lindemann1, Axel Wetter2, Nika Guberina2, Bjoern Jakoby3, and Harald H Quick1,4

1Highfield and Hybrid MR Imaging, University Hospital Essen, Essen, Germany, 2Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany, 3Siemens MR, Siemens Healthcare GmbH, Erlangen, Germany, 4Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen, Germany

A potential challenge of using radiotracer 68-Ga-PSMA for detection and staging of prostate cancer in PET/MR is a frequently observed halo-artifact around the urinary bladder caused by improper scatter correction (SC). Tumor manifestations in these regions might be non-detectable or show distorted SUVs. To evaluate the impact of SC on 68-Ga-PSMA PET/MR imaging, PET data sets of 100 patients were reconstructed twice using standard and improved SC. The improved SC significantly reduces the halo-artifact around the bladder. Measured SUVs in the halo margin on average increased by 325 %, and therefore, considerably affect quantitative assessment of prostate cancer in PET/MR.

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