Abstract #4365

Innate immune cell tracking in the glioma microenvironment by correlated magnetic resonance imaging and multi photon microscopy (MR-MPM)

Kianush Karimian-Jazi^1,2, Philipp Münch^1,3, Allen Alexander^1,3, Manuel Piechutta², Matthia Karreman², Gergely Solecki², Anna Sophie Berghoff², Wolfgang Wick^2,4, Sabine Heiland¹, Martin Bendszus¹, Michael Platten^3,5, Frank Winkler^2,4, and Michael Oliver Breckwoldt^1,3

¹Neuroradiology, Neuroradiology Department, University Hospital Heidelberg, Heidelberg, Germany, ²Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ), Heidelberg, Germany, ³Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁴Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany, ⁵Department of Neurology, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany

The tumor microenvironment (TME) plays a key role for tumor biology. Composition of the TME correlates with overall survival and governs therapy response. Non invasive assessment of the TME has been notoriously difficult. We have designed an imaging strategy to non invasively visualize innate immune cell dynamics in the TME by correlated MRI and multiphoton microscopy. This approach allowed us to visualize the single steps of nanoparticle uptake by blood born monocytes that give rise to tumor macrophages in an experimental glioma model. We further found that nanoparticle uptake also occurs via the disrupted blood-brain barrier into the brain parenchyma where NP are taken up by tumor associated microglia.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.