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Abstract #4366

Specific quantification of 57Fe-nanoparticles by combined MRI and Mass Spectrometric Imaging

Max Masthoff1, Andre Beuker1, Rebeccca Buchholz2, Lydia Wachsmuth1, Walter Heindel1, Uwe Karst2, Moritz Wildgruber1, and Cornelius Faber1

1Institute of Clinical Radiology, University of Muenster, Muenster, Germany, 2Institute for Inorganic and Analytical Chemistry, University of Muenster, Muenster, Germany

Iron oxide nanoparticles (ION) provide high sensitivity for MRI cell tracking, but signal reductions cannot easily be separated from those originating from endogenous iron. We combine 57Fe-ION MRI with laser ablation-inductively coupled plasma-mass spectrometry for differentiation between endogenous iron (56Fe) and applied ION. We establish 57Fe-ION as contrast agent and assess their long-term fate. The technique facilitates specific and quantifiable cell tracking. ION were first internalized by phagocyting cells predominantly in liver and spleen, but in the long-term relocated to endogenous iron sources as the blood or red pulp of the spleen and, interestingly, also in the brain parenchyma.

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