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Abstract #4367

In vivo detection and quantification of plaque rupture using a novel fibrin-binding PET tracer

David Izquierdo-Garcia1, Himashinie Diyabalanage1, Ian Ramsay1, Nick Rotile1, Adam Mauskapf2, Ji-Kyung Choi1, Thomas Witzel1, Anna-Liisa Brownell3, Ciprian Catana1, Peter Caravan1, and Ilknur Ay1

1Athinoula A. Martinos Center for Biomedical Imaging, MGH / Harvard Medical School, Charlestown, MA, United States, 2Department of Medicine, Massachusetts General Hospital, Boston, MA, United States, 3Gordon Center for Medical Imaging, Massachusetts General Hospital, Boston, MA, United States

Detecting high-risk atherosclerotic plaques prone to rupture is still one of the main challenges in cardiovascular imaging that could help save many lives.

This study presents a novel fibrin-binding positron emission tomography (PET) radiotracer, 68Ga-CM246, which allows accurate detection and quantification of plaque rupture in an animal model of atherosclerosis using simultaneous PET/MRI. Our in vivo PET results show that 68Ga-CM246 is highly sensitive and very specific to fibrin clots in ruptured plaques.

Our results confirm the potential of the 68Ga-CM246 to translate into the clinic to identify in humans those plaques at risk of rupture showing intraplaque hemorrhage.

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