Abstract #4369

Fluorine-19 (19F) Labeled Benzothiazole Derivative as a Biosensor for detection of Alzheimer’s Disease using Magnetic Resonance Imaging

Yurii Shepelytskyi¹, Michael G Campbell^2,3, Francis T Hane^2,3, Tao Li³, Vitalii Solomin⁴, Vira Grynko¹, and Mitchell S Albert^2,3,5

¹Chemistry and Materials Science Program, Lakehead University, Thunder Bay, ON, Canada, ²Chemistry, Lakehead University, Thunder Bay, ON, Canada, ³Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, ⁴Enamine Ltd, Kyiv, Ukraine, ⁵Northern Ontario School of Medicine, Thunder Bay, ON, Canada

There are 5-7 million new cases of Alzheimer’s disease (AD) recorded each year worldwide. Typically, Positron Emission Tomography (PET) is used for the detection of amyloid b plaques allow for diagnosis of AD at early stages. However, PET has poor resolution in comparison to magnetic resonance imaging (MRI). The goal of the presented work was to demonstrate that an MR active derivative of the molecule Thioflavin-T, which contains ¹⁹F (2-[p-(Trifluoromethyl)phenyl]-1,3-benzothiazole (BTZ)), can be used to distinguish between samples of AD brains and healthy rat brains.

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