Abstract #4370

Temperature Sensitive 19F-Substituted Molecules for Combined Proton-/Fluorine-Imaging in a 7 T Whole-Body MRI System

Christian Bruns¹, Markus Plaumann¹, Tim Herrmann¹, Frederike Euchner¹, Suchit Kumar², Rainer Ringleb¹, and Johannes Bernarding¹

¹Institute for Biometrics and Medical Informatics, Otto-von-Guericke University, Magdeburg, Germany, ²Department of Biomicrosystem Technology and Korea Artificial Organ Center, Korea University, Seoul, Korea, Republic of

¹⁹F MR spectroscopy and imaging represent important tools for the development of new MR contrast agents and pharmaceutics. Until now, there are only a few published data that described the influence of temperature changes to the ¹⁹F chemical shifts in aqueous solutions. Temperature coefficients up to ~ 8.7Hz/K were determined. Thermoresponsive agents are of high interest in, e.g. hyperthermia studies. Changes in signal intensity and chemical shift give information of the local temperature. Here, we present novel MR spectroscopic and imaging data, which describe the ¹⁹F MR signal temperature dependency of different fluorinated organic substrates in isotonic saline solution and their temperature calculation methods.

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