Abstract #4371

Overcoming short T2 issue with the use of 3D UTE for imaging of 19F-loaded theranostic nanocapsules

Natalia Łopuszyńska¹, Krzysztof Szczepanowicz², Władysław Węglarz¹, and Piotr Warszyński²

¹Department of Magnetic Resonance Imaging, Institute of Nuclear Physics Polish Academy of Sciences, Kraków, Poland, ²Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Kraków, Poland

The development of heteronuclear magnetic resonance imaging is one of the strategies in a control of a biodistribution of therapeutic agents. Molecules containing ¹⁹F atoms are particularly attractive for use as MRI markers due to favorable physical properties of fluorine nucleus. Advances in MRI instrumentation and ultrafast pulse sequence development expanded the range of fluorine compounds available as new MRI markers. Optimization of imaging parameters of such sequences enables the visualization of ¹⁹F compounds with the less preferable characteristic. In this paper, we report the application of the 3D UTE sequence at a high field for imaging of compounds with a complex ¹⁹FNMR spectrum and very short T₂.

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