Abstract #4372

Metabolic differences between hyperpolarized 13C pyruvate MRI and 18F-FDG PET imaging in a rat model of spontaneous brain cancer

Mette H. Lauritzen¹, Keshav Datta¹, Milton Merchant², Taichang Jang², Ralph E. Hurd¹, Shie-Chau Liu¹, Lawrence Recht², and Daniel M. Spielman¹

¹Department of Radiology, Stanford University, Stanford, CA, United States, ²Department of Neurology, Stanford University, Stanford, CA, United States

Hyperpolarized [1-¹³C]pyruvate MRI and ¹⁸F-FDG PET imaging signals were compared in a rat model of spontaneous slow growing glioma, which mimics the growth pattern of some human gliomas. No enhancement of ¹⁸F-FDG was observed in the tumor regions relative to normal appearing brain. Hyperpolarized ¹³C MRI however did show metabolic differences in all animals. The present study suggests that hyperpolarized ¹³C MRS potentially may be used to identify and characterize gliomas, which are ¹⁸F-FDG negative.

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