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Abstract #4373

Dynamic Imaging of Vitamin C Pharmacokinetics by 13C Chemical Shift Imaging without Hyperpolarization

Jeffrey Robert Brender1, Shun Kishimoto1, James Mitchell1, and Murali Krishna Cherukuri1

1National Cancer Institute, Bethesda, MD, United States

Intravenously injected vitamin C is re-emerging as a potential chemotherapeutic agent but questions remain about its bioavailability and metabolic fate. Using newly developed methods for signal denoising, we show that is possible to image vitamin C pharmacokinetics by non-hyperpolarized 13C MRI with significant sensitivity and time resolution that the accumulation of vitamin C into a tumor and its metabolism into downstream metabolites can be visualized. Since the method does not rely on hyperpolarization and therefore does not have restrictions on T1 relaxation, it can be potentially extended to other highly tolerated drugs.

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