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Abstract #4374

Liver Fatty Acid Profile Mapping with Accelerated Free-Breathing Spectroscopic Imaging

Miriam Hewlett1, Christa Davis2, David P McAllindon2, Chris V Bowen1,2,3,4, Kimberly D Brewer1,2,3,4, Sharon Clarke2,3, Steven D Beyea1,2,3,4, and James A Rioux1,2,3

1Physics and Atmospheric Science, Dalhousie University, Halifax, NS, Canada, 2Biomedical Translational Imaging Centre (BIOTIC), Halifax, NS, Canada, 3Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada, 4Biomedical Engineering, Dalhousie University, Halifax, NS, Canada

Fat composition in the liver, particularly the amount of polyunsaturated fat, may be important in characterizing NAFLD. Spatially resolved maps of unsaturation indices were generated using an accelerated free-breathing spin echo single point imaging technique. Multiple under-sampling patterns were acquired sequentially to ensure oversampling of the k-space centre even after retrospective motion correction. The technique was validated using a set of oil/water mixture phantoms and evaluated in an in vivo mouse study (N=8).

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