Abstract #4374

Liver Fatty Acid Profile Mapping with Accelerated Free-Breathing Spectroscopic Imaging

Miriam Hewlett¹, Christa Davis², David P McAllindon², Chris V Bowen^1,2,3,4, Kimberly D Brewer^1,2,3,4, Sharon Clarke^2,3, Steven D Beyea^1,2,3,4, and James A Rioux^1,2,3

¹Physics and Atmospheric Science, Dalhousie University, Halifax, NS, Canada, ²Biomedical Translational Imaging Centre (BIOTIC), Halifax, NS, Canada, ³Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada, ⁴Biomedical Engineering, Dalhousie University, Halifax, NS, Canada

Fat composition in the liver, particularly the amount of polyunsaturated fat, may be important in characterizing NAFLD. Spatially resolved maps of unsaturation indices were generated using an accelerated free-breathing spin echo single point imaging technique. Multiple under-sampling patterns were acquired sequentially to ensure oversampling of the k-space centre even after retrospective motion correction. The technique was validated using a set of oil/water mixture phantoms and evaluated in an in vivo mouse study (N=8).

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