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Abstract #4387

A Protocol for Comprehensive Quantitative 3D Ultrashort Echo Time (UTE) Cones MR Imaging of the Knee Joint with Motion Correction

Mei Wu1,2, Wei Zhao1, Jonathan Lee1, Lidi Wan1, Saeed Jerban1, Eric Y Chang1,3, Jiang Du1, and Yajun Ma1

1Department of Radiology, University of California, San Diego, San Diego, CA, United States, 2Department of Radiology, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China, 3Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

We propose a protocol for comprehensive quantitative 3D UTE-Cones imaging of the knee joint with motion correction. The protocol includes 3D UTE-Cones actual flip angle imaging (UTE-Cones-AFI) for T1 measurement, UTE-Cones with variable TEs for T2* measurement, UTE-Cones with adiabatic T preparation for AdiabT measurement, and UTE-Cones-MT for measuring MTR and modeling of macromolecular fraction (f) for various knee joint tissues including the cartilage, menisci, ligaments, tendons and muscle. An elastix motion registration method was used for motion correction. In our study, three knee specimens and 15 volunteers were evaluated. Mean and standard deviation of the measurements for various knee joint tissues are reported.

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