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Abstract #4386

Confounding Factors in Breast Magnetic Resonance Fingerprinting: B1+, Slice Profile and Diffusion Effects

Teresa Nolte1,2, Mariya Doneva3, Thomas Amthor3, Peter Koken3, Nicolas Gross-Weege2, Tianyu Han2, Hannah Scholten2, and Volkmar Schulz2

1Philips Research Europe, Eindhoven, Netherlands, 2Physics of Molecular Imaging Systems, RWTH Aachen University, Aachen, Germany, 3Philips Research Europe, Hamburg, Germany

In this study, we evaluate the effect of three potentially confounding factors (B1+ inhomogeneity, slice profile, diffusion) on the outcome of 2D Magnetic Resonance Fingerprinting measurements in the female breast for six healthy volunteers. Each of these factors was included into an MRF dictionary and matching results were compared to a reference dictionary that excluded the correction. For the given MRF sequence, both B1+ inhomogeneity and slice profile correction affected the quantitative relaxation times in the female breast, whereas this was not the case for diffusion.

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