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Abstract #4390

Development of a 3D UTE MP2RAGE sequence for mouse pulmonary T1 mapping at 7T

Thibaut L Faller1, Colleen R Cardiet1, Wilfried Souleyreau2, Lin Cooley2, Andreas Bikfalvi2, Baudouin Denis de Senneville3, Sylvain Miraux1, and Emeline J Ribot1

1CNRS - Univ. Bordeaux, CRMSB UMR 5536, Bordeaux Cedex, France, 2INSERM, LAMC INSERM U1029, Pessac, France, 3CNRS - Univ. Bordeaux, IMB UMR5251, Talence, France

The 3D Magnetization Prepared 2 Gradient Echo (MP2RAGE) sequence is very useful to obtain high contrasts between brain tissues and between metastases and the surrounding healthy brain at high clinical magnetic fields (≥3T). In order to apply this sequence for the detection and T1 mapping of lung metastases in mice at 7T, major modifications were done. We developed an ultra-short echo time (UTE) MP2RAGE sequence by replacing the Cartesian encoding by a radial one. This encoding enables (i) to shorten echo time to less than 0.1ms and consequently obtain lung T1 maps; and (ii) to track respiration motion through a self-gating strategy to evaluate the displacements of the metastases due to breathing.

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