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Abstract #4391

Model Based Analysis of Complex Difference Images for Measuring Diameters and Velocities of Penetrating Arteries

Xiaopeng Zong1 and Weili Lin1

1Department of Radiology and BRIC, Univeristy of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Pathological changes of penetrating arteries (PAs) may be an important contributing factor of cerebral small vessel disease (SVD). Measurement of PA flow velocity and diameter with phase contrast (PC) MRI remains challenging due to the presence of strong partial volume effects. Here we propose model-based analysis of complex difference (MBAC) images to quantify diameter and velocity of PAs. We demonstrated the accuracy of the MBAC method with simulation and phantom studies. In vivo PA diameter and velocity were obtained for the first time. The MBAC method may serve as a useful tool for understanding the etiopathogenesis of SVD.

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