Abstract #4399

Direct Myelin Volume Fraction Mapping with Correction for Magnetization Transfer and Diffusion Effects Using a Four-pool White Matter Model

Zhe Wu¹, Ilana R. Leppert¹, and David A. Rudko^1,2

¹Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada, ²Department of Biomedical Engineering, McGill University, Montreal, QC, Canada

We propose an accelerated myelin water fraction (MWF) imaging technique that employs wave encoding combined with double inversion-recovery weighting (wave-CAIPI ViSTa) for rapid human brain myelin volume fraction (MVF) measurement. In addition, we investigate the contributions of both magnetization transfer and diffusion to the wave-CAIPI ViSTa MWF signal. A four-pool white matter model and extended phase graph framework are applied for magnetization transfer and diffusion modeling. The proposed MVF mapping method is a promising candidate for measuring white matter properties in human demyelinating conditions with limited dependence on model fitting parameters.

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