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Abstract #4399

Direct Myelin Volume Fraction Mapping with Correction for Magnetization Transfer and Diffusion Effects Using a Four-pool White Matter Model

Zhe Wu1, Ilana R. Leppert1, and David A. Rudko1,2

1Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada, 2Department of Biomedical Engineering, McGill University, Montreal, QC, Canada

We propose an accelerated myelin water fraction (MWF) imaging technique that employs wave encoding combined with double inversion-recovery weighting (wave-CAIPI ViSTa) for rapid human brain myelin volume fraction (MVF) measurement. In addition, we investigate the contributions of both magnetization transfer and diffusion to the wave-CAIPI ViSTa MWF signal. A four-pool white matter model and extended phase graph framework are applied for magnetization transfer and diffusion modeling. The proposed MVF mapping method is a promising candidate for measuring white matter properties in human demyelinating conditions with limited dependence on model fitting parameters.

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