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Abstract #4400

Accelerating Multi-Echo GRASE with CAIPIRINHA for Fast and High-Resolution Myelin Water Imaging

Gian Franco Piredda1,2,3, Tom Hilbert1,2,3, Erick J. Canales-Rodríguez2, Marco Pizzolato3, Reto Meuli2, Josef Pfeuffer4, Jean-Philippe Thiran2,3, and Tobias Kober1,2,3

1Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 2Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, 3LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4Application Development, Siemens Healthcare GmbH, Erlangen, Germany

Impaired myelin plays a central role in a wide range of degenerative brain diseases. A method for non-invasive and in vivo assessment of myelin content within clinically acceptable acquisition times is thus desirable. In this work, a 3D multi-echo gradient and spin-echo (GRASE) sequence was accelerated with CAIPIRINHA to achieve high-resolution and whole-brain myelin imaging in less than ten minutes. Myelin water fraction (MWF) maps were derived from multi-echo GRASE data in a cohort of healthy subjects and values proved to be consistent with MWF maps computed from a conventional multi-echo spin-echo acquisition.

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