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Abstract #4405

Single-point macromolecular proton fraction mapping at 7T in healthy and demyelinated mouse brain

Lucas Soustelle1,2, Maria-Cristina Antal2, Paulo Loureiro de Sousa2, and Laura Harsan2

1Aix-Marseille Univ. CRMBM UMR 7339, Marseille, France, 2Université de Strasbourg, CNRS, ICube, FMTS, Strasbourg, France

Assessment of myelin content in the brain is essential for monitoring pathologies such as multiple sclerosis. Quantitative MRI methods including quantitative magnetization transfer imaging (qMTI) have been employed in animal and human studies to assess demyelination processes. Animal studies have reported high correlations between myelin content and the macromolecular proton fraction (MPF), a metric derived from qMTI. The single-point MPF mapping method requires the acquisition of a single MT-weighted image, hence reducing protocol scan duration. In this work, we propose the adaptation of this method at 7T in a study involving healthy and demyelinated mice.

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