Mapping microvascular parameters from DCE MRI traditionally requires a compromise between temporal resolution, spatial resolution, and volume coverage. This study developed a dual-temporal-resolution-based analysis method which concatenates acquired high temporal (HT) and high spatial (HS) tissue contrast agent concentration curves into a unified HTHS merged volume and then pixel-by-pixel reconstructed the HT first pass concentration curve to a HS resolution before undertaking kinetic analysis. In vivo assessment of this method was undertaken in 12 patients with neurofibromatosis type II, and demonstrated the potential of the new method to provide high spatial resolution kinetic map with HT comparable accuracy and quality.
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